Terapia de REGEN COV como base de terapia inmunomoduladora mixta en pacientes hospitalizados por neumonía por SARS-CoV-2: Serie de casos / REGEN COV Therapy as the Basis of Mixed Immunomodulatory Therapy in Patients Hospitalized for SARS- CoV-2 Pneumonia: Case Series

Los países en desarrollo con sistema de salud de baja inversión encuentran un reto en priorizar el tratamiento de COVID-19 según su eficacia y sus costos. Materiales y métodos: se explora la utilidad hospitalaria de una intervención segura con eficacia ambulatoria comprobada. Se describe la administración de un tratamiento inmunomodulador combinado a base de imdevimab y casirivimab (REGEN COV). Resultados: los resultados individualizados apuntan a resultados prometedores en pacientes de alto riesgo a progresión y mortalidad. Conclusión: se ha demostrado que REGEN COV es eficiente para tratar dicha enfermedad. Sin embargo, se necesitan ensayos clínicos aleatorizados para comprobar su eficacia en combinación. (AU)

Developing countries with low-investment health systems find it challenging to prioritize COVID-19 treatment according to its efficacy and affordability. Materials and methods: therefore, the in-hospital utility of a safe intervention with outpatient efficacy is explored. We describe the administration of immunomodulatory combination therapy based on imdevimab and casirivimab (REGEN COV). Results: individualized results point to promising outcomes in patients at high risk of progression and mortality. Conclusion: REGEN COV has been shown to be efficient in treating said disease. However, randomized clinical trials are needed to verify their efficacy in combination. (AU)

Structural infrasound from a barge collision with the Mississippi river bridge.

The Mississippi River Bridge in Vicksburg, Mississippi, is a seven-span cantilever bridge that is 1033 m long by 20.9 m wide and is part of the Interstate-20 corridor. On March 23, 2011, at approximately 14:30 CST, a barge moving downstream struck a pier of the bridge. An infrasound array located at the U.S. Army Engineer Research and Development Center (ERDC) detected the impact. Finite Element (FE) models were developed to investigate the structural behavior of the bridge due to the impact. The FE models identified events within the infrasound record that were possibly produced by the different modes of vibration of the bridge structure. The emerging technology of structural infrasound monitoring and the potential for using infrasound as a forensic tool is demonstrated with the results of the bridge-barge collision event and capability of deployment in the future.